Antagonistic control of Caenorhabditis elegans germline stem cell proliferation and differentiation by PUF proteins FBF-1 and FBF-2

Antagonistic control of Caenorhabditis elegans germline stem cell proliferation and differentiation by PUF proteins FBF-1 and FBF-2

Stem cells support tissue maintenance, but the mechanisms that coordinate the rate of stem cell self-renewal with differentiation at a population level remain uncharacterized. We find that two PUF family RNA-binding proteins FBF-1 and FBF-2 have opposite effects on Caenorhabditis elegans germline st...

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Bibliographic Details
Main Authors: Xiaobo Wang, Mary Ellenbecker, Benjamin Hickey, Nicholas J Day, Emily Osterli, Mikaya Terzo, Ekaterina Voronina
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-08-01
Series:eLife
Subjects:
germline
PUF
CCR4-NOT
deadenylase
stem cells
cell cycle
Online Access:https://elifesciences.org/articles/52788

Internet

https://elifesciences.org/articles/52788

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