Integrative effect of carvedilol and aerobic exercise training therapies on improving cardiac contractility and remodeling in heart failure mice.

The use of β-blockers is mandatory for counteracting heart failure (HF)-induced chronic sympathetic hyperactivity, cardiac dysfunction and remodeling. Importantly, aerobic exercise training, an efficient nonpharmacological therapy to HF, also counteracts sympathetic hyperactivity in HF and improves...

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Main Authors: Andréa S Vanzelli, Alessandra Medeiros, Natale Rolim, Jan B Bartholomeu, Telma F Cunha, Luiz R G Bechara, Enéas R M Gomes, Katt C Mattos, Raquel Sirvente, Vera Maria Cury Salemi, Charles Mady, Carlos E Negrao, Silvia Guatimosim, Patricia C Brum
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23658728/pdf/?tool=EBI