Increased expression of the oligopeptidase THOP1 is a neuroprotective response to Aβ toxicity

Increased expression of the oligopeptidase THOP1 is a neuroprotective response to Aβ toxicity

In a comprehensive proteomics study aiming at the identification of proteins associated with amyloid-beta (Aβ)-mediated toxicity in cultured cortical neurons, we have identified Thimet oligopeptidase (THOP1). Functional modulation of THOP1 levels in primary cortical neurons demonstrated that its ove...

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Bibliographic Details
Main Authors: Giuseppe Pollio, Jeroen J.M. Hoozemans, Claus A. Andersen, Renza Roncarati, Maria Cristina Rosi, Elise S. van Haastert, Tamara Seredenina, Daniela Diamanti, Stefano Gotta, Anna Fiorentini, Letizia Magnoni, Roberto Raggiaschi, Annemieke J.M. Rozemuller, Fiorella Casamenti, Andrea Caricasole, Georg C. Terstappen
Format: Article
Language:English
Published: Elsevier 2008-07-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Phosphoproteomics
Thimet oligopeptidase
THOP1
RNAi
TgCRND8 mouse
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108000740

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http://www.sciencedirect.com/science/article/pii/S0969996108000740

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