Two Tau binding sites on tubulin revealed by thiol-disulfide exchanges

Two Tau binding sites on tubulin revealed by thiol-disulfide exchanges

Abstract Tau is a Microtubule-associated protein that induces and stabilizes the formation of the Microtubule cytoskeleton and plays an important role in neurodegenerative diseases. The Microtubules binding region of Tau has been determined for a long time but where and how Tau binds to its partner...

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Bibliographic Details
Main Authors: Marlène Martinho, Diane Allegro, Isabelle Huvent, Charlotte Chabaud, Emilien Etienne, Hervé Kovacic, Bruno Guigliarelli, Vincent Peyrot, Isabelle Landrieu, Valérie Belle, Pascale Barbier
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Scientific Reports
Subjects:
Thiol-disulfide Exchange
Label Release
Native Cysteine Residues
Spin Label
Co-sedimentation Assay
Online Access:https://doi.org/10.1038/s41598-018-32096-9

Internet

https://doi.org/10.1038/s41598-018-32096-9

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