Dexmedetomidine attenuates lipopolysaccharide induced acute lung injury in rats by inhibition of caveolin-1 downstream signaling

Dexmedetomidine attenuates lipopolysaccharide induced acute lung injury in rats by inhibition of caveolin-1 downstream signaling

Objective: Toll-like receptor 4(TLR-4)/nuclear factor-kappa B(NF-κB) pathway plays an important role in inducing acute lung injury (ALI). Studies have proved Dexmedetomidine (Dex) inhibits inflammatory response to mitigate lipopolysaccharide (LPS)‐induced ALI and protect against multiorgan injury in...

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Bibliographic Details
Main Authors: Jing Liu, Xinhua Huang, Siping Hu, Huanzhong He, Zhipeng Meng
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Dexmedetomidine
Acute lung injury
Lipopolysaccharide
Caveolin-1
TLR-4
NF-κB
Online Access:http://www.sciencedirect.com/science/article/pii/S075333221932548X

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http://www.sciencedirect.com/science/article/pii/S075333221932548X

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