Human Sinusoidal Subendothelial Cells Regulate Homing and Invasion of Circulating Metastatic Prostate Cancer Cells to Bone Marrow

Human Sinusoidal Subendothelial Cells Regulate Homing and Invasion of Circulating Metastatic Prostate Cancer Cells to Bone Marrow

Subendothelial cells (pericytes) are the clonogenic, multipotent and self-renewing skeletal stem cells (SSCs) found in bone marrow (BM) stroma. They express genes maintaining hematopoietic stem cell (HMC) niche identity and, transplanted in immunocompromised mice, organize the hematopoietic microenv...

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Bibliographic Details
Main Authors: Alessia Funari, Maurizio Alimandi, Luca Pierelli, Valentina Pino, Stefano Gentileschi, Benedetto Sacchetti
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Cancers
Subjects:
bone marrow (BM)
mesenchymal stem cells (MSCs)
skeletal stem cells (SSCs)
pericytes
CD146
metastatic prostate cancer
humanized bone marrow
in vivo assays
Online Access:https://www.mdpi.com/2072-6694/11/6/763

Internet

https://www.mdpi.com/2072-6694/11/6/763

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