The Role of Sodium Hydrogen Exchanger 1 in Dysregulation of Proton Dynamics and Reprogramming of Cancer Metabolism as a Sequela

The Role of Sodium Hydrogen Exchanger 1 in Dysregulation of Proton Dynamics and Reprogramming of Cancer Metabolism as a Sequela

Cancer cells have an unusual regulation of hydrogen ion dynamics that are driven by poor vascularity perfusion, regional hypoxia, and increased glycolysis. All these forces synergize/orchestrate together to create extracellular acidity and intracellular alkalinity. Precisely, they lead to extracellu...

Full description

Bibliographic Details
Main Authors: Rosa Angela Cardone, Khalid Omer Alfarouk, Robert L. Elliott, Saad Saeed Alqahtani, Samrein B. M. Ahmed, Ahmed N. Aljarbou, Maria Raffaella Greco, Stefania Cannone, Stephan Joel Reshkin
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:International Journal of Molecular Sciences
Subjects:
pH and cancer
pH and Warburg metabolism
proton transport in cancer
Na<sup>+</sup>/H<sup>+</sup> exchanger
tumor metabolic microenvironment
Online Access:https://www.mdpi.com/1422-0067/20/15/3694

Internet

https://www.mdpi.com/1422-0067/20/15/3694

Similar Items