Paradoxical Roles of the MAL/Tirap Adaptor in Pathologies

Paradoxical Roles of the MAL/Tirap Adaptor in Pathologies

Toll-like receptors (TLRs) are at the forefront of pathogen recognition ensuring host fitness and eliciting protective cellular and humoral responses. Signaling pathways downstream of TLRs are tightly regulated for preventing collateral damage and loss of tolerance toward commensals. To trigger effe...

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Bibliographic Details
Main Authors: Imène Belhaouane, Eik Hoffmann, Mathias Chamaillard, Priscille Brodin, Arnaud Machelart
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
TLRs
MAL/Tirap
chronic diseases
signaling pathways
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.569127/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.569127/full

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