Interleukin-4 Protects Dopaminergic Neurons In vitro but Is Dispensable for MPTP-Induced Neurodegeneration In vivo

Interleukin-4 Protects Dopaminergic Neurons In vitro but Is Dispensable for MPTP-Induced Neurodegeneration In vivo

Microglia are involved in physiological as well as neuropathological processes in the central nervous system (CNS). Their functional states are often referred to as M1-like and M2-like activation, and are believed to contribute to neuroinflammation-mediated neurodegeneration or neuroprotection, resp...

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Bibliographic Details
Main Authors: Laura Hühner, Jennifer Rilka, Ralf Gilsbach, Xiaolai Zhou, Venissa Machado, Björn Spittau
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-03-01
Series:Frontiers in Molecular Neuroscience
Subjects:
IL4
MPTP
mDA neuron
microglia
neurodegeneration
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00062/full

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