National clinical guidelines for the diagnosis and treatment of paroxysmal nocturnal hemoglobinuria

National clinical guidelines for the diagnosis and treatment of paroxysmal nocturnal hemoglobinuria

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<p>Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired clonal blood disorder caused by somatic mutation of the phosphatidylinositol<br />glycan complementation group A gene (PIG-A) in a hematopoietic stem cell. PNH is characterized by chronic intravascular hemolysis, bone marrow...

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Bibliographic Details
Main Authors: A. D. Kulagin, I. A. Lisukov, V. V. Ptushkin, Ye. R. Shilova, N. V. Tsvetaeva, Ye. A. Mikhailova
Format: Article
Language:Russian
Published: ABV-press 2014-09-01
Series:Onkogematologiâ
Subjects:
paroxysmal nocturnal hemoglobinuria
aplastic anemia
complement
hemolysis
flow cytometry
thrombosis
bone marrow transplantation
eculizumab
Online Access:http://oncohematology.abvpress.ru/index.php/ongm/article/view/111

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http://oncohematology.abvpress.ru/index.php/ongm/article/view/111

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