Interplay Between LOX Enzymes and Integrins in the Tumor Microenvironment

Interplay Between LOX Enzymes and Integrins in the Tumor Microenvironment

Members of the lysyl oxidase (LOX) family are secreted copper-dependent amine oxidases that catalyze the covalent crosslinking of collagens and elastin in the extracellular matrix (ECM), an essential process for the structural integrity of all tissues. LOX enzymes can also remodel the tumor microenv...

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Bibliographic Details
Main Authors: Pier Giorgio Amendola, Raphael Reuten, Janine Terra Erler
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Cancers
Subjects:
lysyl oxidase
integrins
adhesion complexes
extracellular matrix
cancer
Online Access:https://www.mdpi.com/2072-6694/11/5/729

Internet

https://www.mdpi.com/2072-6694/11/5/729

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