Drosophila CP190- and dCTCF-mediated enhancer blocking is augmented by SUMOylation

Drosophila CP190- and dCTCF-mediated enhancer blocking is augmented by SUMOylation

Abstract Background Chromatin insulators shield promoters and chromatin domains from neighboring enhancers or chromatin regions with opposing activities. Insulator-binding proteins and their cofactors mediate the boundary function. In general, covalent modification of proteins by the small ubiquitin...

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Bibliographic Details
Main Authors: Theresa Jox, Melanie K. Buxa, Dorte Bohla, Ikram Ullah, Igor Mačinković, Alexander Brehm, Marek Bartkuhn, Rainer Renkawitz
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Epigenetics & Chromatin
Subjects:
Chromatin insulator
CP190
dCTCF
SUMOylation
Fab8
Insulator speckle
Online Access:http://link.springer.com/article/10.1186/s13072-017-0140-6

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http://link.springer.com/article/10.1186/s13072-017-0140-6

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