High content image-based screening of a protease inhibitor library reveals compounds broadly active against Rift Valley fever virus and other highly pathogenic RNA viruses.

High content image-based screening of a protease inhibitor library reveals compounds broadly active against Rift Valley fever virus and other highly pathogenic RNA viruses.

High content image-based screening was developed as an approach to test a protease inhibitor small molecule library for antiviral activity against Rift Valley fever virus (RVFV) and to determine their mechanism of action. RVFV is the causative agent of severe disease of humans and animals throughout...

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Bibliographic Details
Main Authors: Rajini Mudhasani, Krishna P Kota, Cary Retterer, Julie P Tran, Chris A Whitehouse, Sina Bavari
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-08-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC4140764?pdf=render

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http://europepmc.org/articles/PMC4140764?pdf=render

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