Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcriptional regulator.

Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcriptional regulator.

The mycobacterial type VII secretion system ESX-1 is responsible for the secretion of a number of proteins that play important roles during host infection. The regulation of the expression of secreted proteins is often essential to establish successful infection. Using transcriptome sequencing, we f...

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Bibliographic Details
Main Authors: Abdallah M Abdallah, Eveline M Weerdenburg, Qingtian Guan, Roy Ummels, Stephanie Borggreve, Sabir A Adroub, Tareq B Malas, Raeece Naeem, Huoming Zhang, Thomas D Otto, Wilbert Bitter, Arnab Pain
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0211003

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https://doi.org/10.1371/journal.pone.0211003

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