Insulin/IGF1 signalling mediates the effects of β2‐adrenergic agonist on muscle proteostasis and growth

Insulin/IGF1 signalling mediates the effects of β2‐adrenergic agonist on muscle proteostasis and growth

Abstract Background Stimulation of β2‐adrenoceptors can promote muscle hypertrophy and fibre type shift, and it can counteract atrophy and weakness. The underlying mechanisms remain elusive. Methods Fed wild type (WT), 2‐day fasted WT, muscle‐specific insulin (INS) receptor (IR) knockout (M‐IR−/−),...

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Bibliographic Details
Main Authors: Dawit A. Gonçalves, Wilian A. Silveira, Leandro H. Manfredi, Flávia A. Graça, Andrea Armani, Enrico Bertaggia, Brian T. O´Neill, Natalia Lautherbach, Juliano Machado, Leonardo Nogara, Marcelo G. Pereira, Diletta Arcidiacono, Stefano Realdon, C. Ronald Kahn, Marco Sandri, Isis C. Kettelhut, Luiz Carlos C. Navegantes
Format: Article
Language:English
Published: Wiley 2019-04-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
β2‐adrenoceptor
Insulin/IGF1 signalling
Protein metabolism
Skeletal muscle function
Skeletal muscle plasticity
Autophagy‐lysosomal system
Online Access:https://doi.org/10.1002/jcsm.12395

Internet

https://doi.org/10.1002/jcsm.12395

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