Drug affinity and targeted delivery: double functionalization of silk spheres for controlled doxorubicin delivery into Her2-positive cancer cells

Drug affinity and targeted delivery: double functionalization of silk spheres for controlled doxorubicin delivery into Her2-positive cancer cells

Abstract Background The optimal drug delivery system should be biocompatible, biodegradable, and allow the sustained release of the drug only after it reaches the target cells. Silk, as a natural polymer, is a great candidate for building drug carriers. Genetically engineered silks offer the possibi...

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Bibliographic Details
Main Authors: Kamil Kucharczyk, Anna Florczak, Tomasz Deptuch, Karolina Penderecka, Katarzyna Jastrzebska, Andrzej Mackiewicz, Hanna Dams-Kozlowska
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Journal of Nanobiotechnology
Subjects:
Silk
Genetic engineering
Spheres
Drug carrier
Doxorubicin
Cancer
Online Access:http://link.springer.com/article/10.1186/s12951-020-00609-2

Internet

http://link.springer.com/article/10.1186/s12951-020-00609-2

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