The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations

Lamin B receptor (LBR) is a polytopic membrane protein residing in the inner nuclear membrane in association with the nuclear lamina. We demonstrate that human LBR is essential for cholesterol synthesis. LBR mutant derivatives implicated in Greenberg skeletal dysplasia or Pelger-Huët anomaly fail to...

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Bibliographic Details
Main Authors: Pei-Ling Tsai, Chenguang Zhao, Elizabeth Turner, Christian Schlieker
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-06-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/16011