Heterogeneities in Cell Cycle Checkpoint Activation Following Doxorubicin Treatment Reveal Targetable Vulnerabilities in <i>TP53</i> Mutated Ultra High-Risk Neuroblastoma Cell Lines

Heterogeneities in Cell Cycle Checkpoint Activation Following Doxorubicin Treatment Reveal Targetable Vulnerabilities in <i>TP53</i> Mutated Ultra High-Risk Neuroblastoma Cell Lines

Most chemotherapeutics target DNA integrity and thereby trigger tumour cell death through activation of DNA damage responses that are tightly coupled to the cell cycle. Disturbances in cell cycle regulation can therefore lead to treatment resistance. Here, a comprehensive analysis of cell cycle chec...

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Bibliographic Details
Main Authors: Linnéa Ödborn Jönsson, Maryam Sahi, Ximena Lopez-Lorenzo, Faye Leilah Keller, Ourania N. Kostopoulou, Nikolas Herold, Lars Ährlund-Richter, Shahrzad Shirazi Fard
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
ATM
cell cycle arrest
DNA damage
drug-resistance
high-risk neuroblastoma
mitotic-arrest
Online Access:https://www.mdpi.com/1422-0067/22/7/3664

Internet

https://www.mdpi.com/1422-0067/22/7/3664

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