Susceptibility of striatal neurons to excitotoxic injury correlates with basal levels of Bcl-2 and the induction of P53 and c-Myc immunoreactivity

Susceptibility of striatal neurons to excitotoxic injury correlates with basal levels of Bcl-2 and the induction of P53 and c-Myc immunoreactivity

The present studies evaluated the potential contribution of Bcl-2, p53, and c-Myc to the differential vulnerability of striatal neurons to the excitotoxin quinolinic acid (QA). In normal rat striatum, Bcl-2 immunoreactivity (Bcl-2-i) was most intense in large aspiny interneurons including choline ac...

Full description

Bibliographic Details
Main Authors: Zhong-Qin Liang, Xiao-Xia Wang, Yumei Wang, De-Maw Chuang, Marian DiFiglia, Thomas N. Chase, Zheng-Hong Qin
Format: Article
Language:English
Published: Elsevier 2005-11-01
Series:Neurobiology of Disease
Subjects:
Huntington's disease
Excitotoxicity
Striatum
Apoptosis
Neurodegeneration
Cholinergic interneurons
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105001178

Internet

http://www.sciencedirect.com/science/article/pii/S0969996105001178

Similar Items