Neonatal leptin treatment reverses the bone-suppressive effects of maternal undernutrition in adult rat offspring

Abstract Alterations in the early life environment, including maternal undernutrition (UN) during pregnancy, can lead to increased risk of metabolic and cardiovascular disorders in offspring. Leptin treatment of neonates born to UN rats reverses the programmed metabolic phenotype, but the possible b...

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Bibliographic Details
Main Authors: Elwyn C. Firth, Greg D. Gamble, Jillian Cornish, Mark H. Vickers
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-07500-5