The linoleic acid derivative DCP-LA selectively activates PKC-ɛ, possibly binding to the phosphatidylserine binding site

This study examined the effect of 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA), a newly synthesized linoleic acid derivative with cyclopropane rings instead of cis-double bonds, on protein kinase C (PKC) activity. In the in situ PKC assay with reverse-phase high-performance...

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Bibliographic Details
Main Authors:	Takeshi Kanno, Hideyuki Yamamoto, Takahiro Yaguchi, Rika Hi, Takeshi Mukasa, Hirokazu Fujikawa, Tetsu Nagata, Satoshi Yamamoto, Akito Tanaka, Tomoyuki Nishizaki
Format:	Article
Language:	English
Published:	Elsevier 2006-06-01
Series:	Journal of Lipid Research
Subjects:	8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid protein kinase C-ɛ protein kinase C-γ
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520332132

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http://www.sciencedirect.com/science/article/pii/S0022227520332132

The linoleic acid derivative DCP-LA selectively activates PKC-ɛ, possibly binding to the phosphatidylserine binding site

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