Design of a glutamine substrate tag enabling protein labelling mediated by Bacillus subtilis transglutaminase.

Transglutaminases (TGases) are enzymes that catalyse protein cross-linking through a transamidation reaction between the side chain of a glutamine residue on one protein and the side chain of a lysine residue on another. Generally, TGases show low substrate specificity with respect to their amine su...

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Bibliographic Details
Main Authors: Samuel K Oteng-Pabi, Christopher M Clouthier, Jeffrey W Keillor
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5976192?pdf=render