Integrated laboratory evolution and rational engineering of GalP/Glk-dependent Escherichia coli for higher yield and productivity of L-tryptophan biosynthesis

L-Tryptophan (Trp) is a high-value aromatic amino acid with diverse applications in food and pharmaceutical industries. Although production of Trp by engineered Escherichia coli has been extensively studied, the need of multiple precursors for its synthesis and the complex regulations of the biosynt...

Full description

Bibliographic Details
Main Authors: Chen Minliang, Ma Chengwei, Chen Lin, An-Ping Zeng
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Metabolic Engineering Communications
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2214030121000079