MRE11-RAD50-NBS1 complex alterations and DNA damage response: implications for cancer treatment

MRE11-RAD50-NBS1 complex alterations and DNA damage response: implications for cancer treatment

Abstract Genome instability is a hallmark of cancer cells and can be accelerated by defects in cellular responses to DNA damage. This feature of malignant cells opens new avenues for tumor targeted therapy. MRE11-RAD50-NBS1 complex plays a crucial role in sensing and repair of DNA damage. Through in...

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Bibliographic Details
Main Authors: Lei Bian, Yiling Meng, Meichao Zhang, Dong Li
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Molecular Cancer
Subjects:
MRN complex
DNA damage response
tumorigenesis
chemotherapy
radiotherapy
Online Access:http://link.springer.com/article/10.1186/s12943-019-1100-5

Internet

http://link.springer.com/article/10.1186/s12943-019-1100-5

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