Methylglyoxal interaction with superoxide dismutase 1

Methylglyoxal (MG) is a highly reactive aldehyde spontaneously formed in human cells mainly as a by-product of glycolysis. Such endogenous metabolite reacts with proteins, nucleotides and lipids forming advanced glycation end-products (AGEs). MG binds to arginine, lysine and cysteine residues of pro...

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Bibliographic Details
Main Authors: Panagis Polykretis, Enrico Luchinat, Francesca Boscaro, Lucia Banci
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231719313473