Small molecule suppressors of Drosophila kinesin deficiency rescue motor axon development in a zebrafish model of spinal muscular atrophy.

Small molecule suppressors of Drosophila kinesin deficiency rescue motor axon development in a zebrafish model of spinal muscular atrophy.

Proximal spinal muscular atrophy (SMA) is the most common inherited motor neuropathy and the leading hereditary cause of infant mortality. Currently there is no effective treatment for the disease, reflecting a need for pharmacologic interventions that restore performance of dysfunctional motor neur...

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Bibliographic Details
Main Authors: Andrew Gassman, Le T Hao, Leena Bhoite, Chad L Bradford, Chi-Bin Chien, Christine E Beattie, John P Manfredi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3762770?pdf=render

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http://europepmc.org/articles/PMC3762770?pdf=render

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