hERG-deficient human embryonic stem cell-derived cardiomyocytes for modelling QT prolongation

hERG-deficient human embryonic stem cell-derived cardiomyocytes for modelling QT prolongation

Abstract Background Long-QT syndrome type 2 (LQT2) is a common malignant hereditary arrhythmia. Due to the lack of suitable animal and human models, the pathogenesis of LQT2 caused by human ether-a-go-go-related gene (hERG) deficiency is still unclear. In this study, we generated an hERG-deficient h...

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Bibliographic Details
Main Authors: Yun Chang, Ya-nan Li, Rui Bai, Fujian Wu, Shuhong Ma, Amina Saleem, Siyao Zhang, Youxu Jiang, Tao Dong, Tianwei Guo, Chengwen Hang, Wen-jing Lu, Hongfeng Jiang, Feng Lan
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Stem Cell Research & Therapy
Subjects:
Human ether-a-go-go-related gene
KCNH2
hESCs
QT prolongation
CRISPR/Cas9
Online Access:https://doi.org/10.1186/s13287-021-02346-1

Internet

https://doi.org/10.1186/s13287-021-02346-1

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