USP49 negatively regulates cellular antiviral responses via deconjugating K63-linked ubiquitination of MITA.

USP49 negatively regulates cellular antiviral responses via deconjugating K63-linked ubiquitination of MITA.

Mediator of IRF3 activation (MITA, also known as STING and ERIS) is an essential adaptor protein for cytoplasmic DNA-triggered signaling and involved in innate immune responses, autoimmunity and tumorigenesis. The activity of MITA is critically regulated by ubiquitination and deubiquitination. Here,...

Full description

Bibliographic Details
Main Authors: Liya Ye, Qiang Zhang, Tianzi Liuyu, Zhigao Xu, Meng-Xin Zhang, Min-Hua Luo, Wen-Bo Zeng, Qiyun Zhu, Dandan Lin, Bo Zhong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-04-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC6464240?pdf=render

Internet

http://europepmc.org/articles/PMC6464240?pdf=render

Similar Items