Ultra-Rapid Glutathionylation of Ribonuclease: Is This the Real Incipit of Its Oxidative Folding?

Ultra-Rapid Glutathionylation of Ribonuclease: Is This the Real Incipit of Its Oxidative Folding?

Many details of oxidative folding of proteins remain obscure, in particular, the role of oxidized glutathione (GSSG). This study reveals some unknown aspects. When a reduced ribonuclease A refolds in the presence of GSSG, most of its eight cysteines accomplish a very fast glutathionylation. In parti...

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Bibliographic Details
Main Authors: Alessio Bocedi, Giada Cattani, Giorgia Gambardella, Silvia Ticconi, Flora Cozzolino, Ornella Di Fusco, Piero Pucci, Giorgio Ricci
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:International Journal of Molecular Sciences
Subjects:
ribonuclease
glutathionylation
oxidative folding
molten globule
cysteine reactivity
Online Access:https://www.mdpi.com/1422-0067/20/21/5440

Internet

https://www.mdpi.com/1422-0067/20/21/5440

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