Abnormal Glucose Metabolism and Insulin Resistance Are Induced via the IRE1α/XBP-1 Pathway in Subclinical Hypothyroidism

Abnormal Glucose Metabolism and Insulin Resistance Are Induced via the IRE1α/XBP-1 Pathway in Subclinical Hypothyroidism

Subclinical hypothyroidism (SCH) and diabetes mellitus are closely related and often occur together in individuals. However, the underlying mechanism of this association is still uncertain. In this study we re-analyzed the data of a mature database (NHANES, 1999 ~ 2002) and found that both fasting p...

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Bibliographic Details
Main Authors: Chao Xu, Lingyan Zhou, Kunpeng Wu, Yujie Li, Jin Xu, Dongqing Jiang, Ling Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Endocrinology
Subjects:
glucose impairment
Subclinical hypothyroidism
insulin resistance
ER stress
IRE1α/XBP-1
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00303/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2019.00303/full

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