The interplay of RNA:DNA hybrid structure and G-quadruplexes determines the outcome of R-loop-replisome collisions

The interplay of RNA:DNA hybrid structure and G-quadruplexes determines the outcome of R-loop-replisome collisions

R-loops are a major source of genome instability associated with transcription-induced replication stress. However, how R-loops inherently impact replication fork progression is not understood. Here, we characterize R-loop-replisome collisions using a fully reconstituted eukaryotic DNA replication s...

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Bibliographic Details
Main Authors: Charanya Kumar, Sahil Batra, Jack D Griffith, Dirk Remus
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-09-01
Series:eLife
Subjects:
DNA replication
R-loop
G-quadruplex
Pif1
RNase H
replisome
Online Access:https://elifesciences.org/articles/72286

Internet

https://elifesciences.org/articles/72286

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