Application of the PET ligand [11C]ORM-13070 to examine receptor occupancy by the α2C-adrenoceptor antagonist ORM-12741: translational validation of target engagement in rat and human brain

Application of the PET ligand [11C]ORM-13070 to examine receptor occupancy by the α2C-adrenoceptor antagonist ORM-12741: translational validation of target engagement in rat and human brain

Abstract Background Availability of the α2C-adrenoceptor (α2C-AR) positron emission tomography (PET) tracer, [11C]ORM-13070, and the α2C-AR antagonist ORM-12741 allows probing of the roles of this G-protein coupled receptor subtype in brain function, both in healthy humans and in patients with vario...

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Bibliographic Details
Main Authors: Mohammed Shahid, Juha O. Rinne, Mika Scheinin, Jere Virta, Päivi Marjamäki, Olof Solin, Eveliina Arponen, Jukka Sallinen, Katja Kuokkanen, Juha Rouru
Format: Article
Language:English
Published: SpringerOpen 2020-12-01
Series:EJNMMI Research
Subjects:
Brain α2C-adrenoceptors
Receptor occupancy
ORM-12741
[11C]ORM-13070 PET
α2C-Adrenoceptor antagonists
Online Access:https://doi.org/10.1186/s13550-020-00741-y

Internet

https://doi.org/10.1186/s13550-020-00741-y

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