Development of an Innovative in Vitro Potency Assay for Anti-Botulinum Antitoxins

Botulinum neurotoxins are bacterial proteins that cause botulism, a life-threatening disease. Therapy relies mostly on post-intoxication antibody treatment. The only accepted method to measure the potency of, and to approve, antitoxin preparations is the mouse lethality neutralization bioassay. Howe...

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Bibliographic Details
Main Authors: Osnat Rosen, Eyal Ozeri, Ada Barnea, Alon Ben David, Ran Zichel
Format: Article
Language:English
Published: MDPI AG 2016-09-01
Series:Toxins
Subjects:
Online Access:http://www.mdpi.com/2072-6651/8/10/276