An Intrinsically Disordered Peptide from Ebola Virus VP35 Controls Viral RNA Synthesis by Modulating Nucleoprotein-RNA Interactions

An Intrinsically Disordered Peptide from Ebola Virus VP35 Controls Viral RNA Synthesis by Modulating Nucleoprotein-RNA Interactions

During viral RNA synthesis, Ebola virus (EBOV) nucleoprotein (NP) alternates between an RNA-template-bound form and a template-free form to provide the viral polymerase access to the RNA template. In addition, newly synthesized NP must be prevented from indiscriminately binding to noncognate RNAs. H...

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Bibliographic Details
Main Authors: Daisy W. Leung, Dominika Borek, Priya Luthra, Jennifer M. Binning, Manu Anantpadma, Gai Liu, Ian B. Harvey, Zhaoming Su, Ariel Endlich-Frazier, Juanli Pan, Reed S. Shabman, Wah Chiu, Robert A. Davey, Zbyszek Otwinowski, Christopher F. Basler, Gaya K. Amarasinghe
Format: Article
Language:English
Published: Elsevier 2015-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715003034

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http://www.sciencedirect.com/science/article/pii/S2211124715003034

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