Preformed CD40L is stored in Th1, Th2, Th17, and T follicular helper cells as well as CD4+ 8- thymocytes and invariant NKT cells but not in Treg cells.

Preformed CD40L is stored in Th1, Th2, Th17, and T follicular helper cells as well as CD4+ 8- thymocytes and invariant NKT cells but not in Treg cells.

CD40L is essential for the development of adaptive immune responses. It is generally thought that CD40L expression in CD4(+) T cells is regulated transcriptionally and made from new mRNA following antigen recognition. However, imaging studies show that the majority of cognate interactions between ef...

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Bibliographic Details
Main Authors: Yoshinobu Koguchi, Abigail C Buenafe, Timothy J Thauland, Jennifer L Gardell, Elizabeth R Bivins-Smith, David B Jacoby, Mark K Slifka, David C Parker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3283616?pdf=render

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http://europepmc.org/articles/PMC3283616?pdf=render

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