Modeling Cu2+-Aβ complexes from computational approaches

Amyloid plaques formation and oxidative stress are two key events in the pathology of the Alzheimer disease (AD), in which metal cations have been shown to play an important role. In particular, the interaction of the redox active Cu2+ metal cation with Aβ has been found to interfere in amyloid aggr...

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Bibliographic Details
Main Authors: Jorge Alí-Torres, Andrea Mirats, Jean-Didier Maréchal, Luis Rodríguez-Santiago, Mariona Sodupe
Format: Article
Language:English
Published: AIP Publishing LLC 2015-09-01
Series:AIP Advances
Online Access:http://dx.doi.org/10.1063/1.4921072