Distinct submembrane localisation compartmentalises cardiac NPR1 and NPR2 signalling to cGMP

Distinct submembrane localisation compartmentalises cardiac NPR1 and NPR2 signalling to cGMP

Natriuretic peptides (NPs) are important hormones that regulate cardiovascular physiology by increasing cGMP levels in cardiomyocytes. Here the authors use scanning ion conductance microscopy and a cGMP FRET sensor to identify a differential localisation pattern for the natriuretic peptide receptors...

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Bibliographic Details
Main Authors: Hariharan Subramanian, Alexander Froese, Peter Jönsson, Hannes Schmidt, Julia Gorelik, Viacheslav O. Nikolaev
Format: Article
Language:English
Published: Nature Publishing Group 2018-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04891-5
Description
Summary:Natriuretic peptides (NPs) are important hormones that regulate cardiovascular physiology by increasing cGMP levels in cardiomyocytes. Here the authors use scanning ion conductance microscopy and a cGMP FRET sensor to identify a differential localisation pattern for the natriuretic peptide receptors within the heart.
ISSN:2041-1723

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