Conditional expression of human β-hexosaminidase in the neurons of Sandhoff disease rescues mice from neurodegeneration but not neuroinflammation

Conditional expression of human β-hexosaminidase in the neurons of Sandhoff disease rescues mice from neurodegeneration but not neuroinflammation

<p>Abstract</p> <p>This study evaluated whether GM<sub>2</sub> ganglioside storage is necessary for neurodegeneration and neuroinflammation by performing β-hexosaminidase rescue experiments in neurons of HexB<sup>−/−</sup> mice. We developed a novel mouse mo...

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Bibliographic Details
Main Authors: Kyrkanides Stephanos, Brouxhon Sabine M, Tallents Ross H, Miller Jen-nie H, Olschowka John A, O’Banion M
Format: Article
Language:English
Published: BMC 2012-08-01
Series:Journal of Neuroinflammation
Subjects:
GM<sub>2</sub> gangliosidosis
β-hexosaminidase
Mouse
Neuron
Sandhoff disease
Transgenic
Online Access:http://www.jneuroinflammation.com/content/9/1/186

Internet

http://www.jneuroinflammation.com/content/9/1/186

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