Hologram QSAR Models of 4-[(Diethylamino)methyl]-phenol Inhibitors of Acetyl/Butyrylcholinesterase Enzymes as Potential Anti-Alzheimer Agents

Hologram QSAR Models of 4-[(Diethylamino)methyl]-phenol Inhibitors of Acetyl/Butyrylcholinesterase Enzymes as Potential Anti-Alzheimer Agents

Hologram QSAR models were developed for a series of 36 inhibitors (29 training set and seven test set compounds) of acetyl/butyrylcholinesterase (AChE/BChE) enzymes, an attractive molecular target for Alzheimer’s disease (AD) treatment. The HQSAR models (N = 29) exhibited significant cross-validated...

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Bibliographic Details
Main Authors: Carlos Rangel Rodrigues, Magaly Girão Albuquerque, Helena Carla Castro, Lúcio Mendes Cabral, Ana Carolina Corrêa de Sousa, Ana Carolina Rennó Sodero, Alessandra Mendonça Teles de Souza, Simone Decembrino de Souza
Format: Article
Language:English
Published: MDPI AG 2012-08-01
Series:Molecules
Subjects:
HQSAR
acetylcholinesterase
butyrylcholinesterase
Alzheimer’s disease (AD)
Online Access:http://www.mdpi.com/1420-3049/17/8/9529

Internet

http://www.mdpi.com/1420-3049/17/8/9529

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