Identification and Splicing Characterization of Novel TMC6 and TMC8 Variants Associated With Epidermodysplasia Verruciformis in Three Chinese Families

Identification and Splicing Characterization of Novel TMC6 and TMC8 Variants Associated With Epidermodysplasia Verruciformis in Three Chinese Families

Background: Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by abnormal susceptibility to human beta papillomavirus infections and a particular propensity to develop non-melanoma skin cancers (NMSCs). The majority of EV cases are caused by biallelic null variants in TMC6,...

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Bibliographic Details
Main Authors: Rongrong Wang, Jiawei Liu, Xueting Yang, Xiaerbati Habulieti, Xue Yu, Liwei Sun, Han Zhang, Yang Sun, Donglai Ma, Xue Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Genetics
Subjects:
epidermodysplasia verruciformis
human beta HPV
TMC6
TMC8
pathogenic variants
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.712275/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2021.712275/full

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