Illuminating the off-pathway nature of the molten globule folding intermediate of an α-β parallel protein.

Partially folded protein species transiently form during folding of most proteins. Often, these species are molten globules, which may be on- or off-pathway to the native state. Molten globules are ensembles of interconverting protein conformers that have a substantial amount of secondary structure,...

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Bibliographic Details
Main Authors: Simon Lindhoud, Adrie H Westphal, Jan Willem Borst, Carlo P M van Mierlo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23029219/pdf/?tool=EBI