Ketamine Administration Reverses Corticosterone-Induced Alterations in Excitatory and Inhibitory Transmission in the Rat Dorsal Raphe Nucleus

Ketamine, a N-methyl-D-aspartate (NMDA) receptor antagonist, exerts rapid antidepressant effects in human patients and ameliorates depressive-like behavioral effects of chronic stress in animal models. Chronic stress and elevated corticosterone levels have been shown to modify serotonin (5-HT) neuro...

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Bibliographic Details
Main Authors: Joanna Sowa, Magdalena Kusek, Bartosz Bobula, Grzegorz Hess, Krzysztof Tokarski
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:Neural Plasticity
Online Access:http://dx.doi.org/10.1155/2019/3219490