Facile Amberlyst A-21 catalyzed access of β-hydroxynitriles via epoxide opening in water

Facile Amberlyst A-21 catalyzed access of β-hydroxynitriles via epoxide opening in water

β-Hydroxynitriles are essential intermediates in the synthesis of diverse bioactive compounds and clinical drugs. One of the precursor reactions to these intermediates is the opening of an epoxide ring with a cyanide nucleophile. In the present study, we report a milder and safer route to β-hydroxyn...

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Bibliographic Details
Main Authors: M. Shaheer Malik, Basim H. Asghar, Shaik Azeeza, Rami J. Obaid, Ismail I. Thagafi, Rabab.S. Jassas, Hatem M. Altass, Moataz Morad, Ziad Moussa, Saleh A. Ahmed
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Arabian Journal of Chemistry
Subjects:
β-Hydroxynitriles
Epoxide opening
Amberlyst A-21
Acetone cyanohydrin
Water
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535220303877

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http://www.sciencedirect.com/science/article/pii/S1878535220303877

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