Porcine reproductive and respiratory syndrome virus inhibits MARC-145 proliferation via inducing apoptosis and G2/M arrest by activation of Chk/Cdc25C and p53/p21 pathway

Porcine reproductive and respiratory syndrome virus inhibits MARC-145 proliferation via inducing apoptosis and G2/M arrest by activation of Chk/Cdc25C and p53/p21 pathway

Abstract Porcine reproductive and respiratory syndrome virus(PRRSV) is an important immunosuppressive virus which can suppresses infected cells proliferation. In this work, we examined PRRSV ability to manipulate cell cycle progression of MARC-145 cells and explored the potential molecular mechanism...

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Bibliographic Details
Main Authors: Linlin Song, Ximeng Han, Cunyu Jia, Xin Zhang, Yunjie Jiao, Taofeng Du, Shuqi Xiao, Julian A. Hiscox, En-Min Zhou, Yang Mu
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Virology Journal
Subjects:
Porcine reproductive and respiratory syndrome virus
G2/M arrest
Cdc2-cyclinB1 complex
Cdc25C
p53
Online Access:http://link.springer.com/article/10.1186/s12985-018-1081-9

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http://link.springer.com/article/10.1186/s12985-018-1081-9

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