Fibroblasts from idiopathic Parkinson’s disease exhibit deficiency of lysosomal glucocerebrosidase activity associated with reduced levels of the trafficking receptor LIMP2

Fibroblasts from idiopathic Parkinson’s disease exhibit deficiency of lysosomal glucocerebrosidase activity associated with reduced levels of the trafficking receptor LIMP2

Abstract Lysosomal dysfunction is a central pathway associated with Parkinson’s disease (PD) pathogenesis. Haploinsufficiency of the lysosomal hydrolase GBA (encoding glucocerebrosidase (GCase)) is one of the largest genetic risk factors for developing PD. Deficiencies in the activity of the GCase e...

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Bibliographic Details
Main Authors: Ria Thomas, Elizabeth B. Moloney, Zachary K. Macbain, Penelope J. Hallett, Ole Isacson
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Molecular Brain
Subjects:
GBA
LIMP2
Idiopathic PD fibroblasts
Lysosomal dysfunction
Online Access:https://doi.org/10.1186/s13041-020-00712-3

Internet

https://doi.org/10.1186/s13041-020-00712-3

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