Hypoxia-induced Tie1 drives stemness and cisplatin resistance in non-small cell lung carcinoma cells

Hypoxia-induced Tie1 drives stemness and cisplatin resistance in non-small cell lung carcinoma cells

Abstract Background Drug resistance and metastasis involving hypoxic tumor environments and persistent stem cell populations are detrimental to the survival of patients with non-small cell lung carcinoma (NSCLC). Tie1 is upregulated in hypoxia and is believed to counteract the effectiveness of plati...

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Bibliographic Details
Main Authors: Chaojie Li, Nannan Yang, Zhijin Chen, Ning Xia, Qungang Shan, Ziyin Wang, Jian Lu, Mingyi Shang, Zhongmin Wang
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Cancer Cell International
Subjects:
Tie1
Hypoxia
Stemness
HIF-1α
Cisplatin resistance
Online Access:https://doi.org/10.1186/s12935-020-01729-3

Internet

https://doi.org/10.1186/s12935-020-01729-3

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