Topical Diclofenac Reprograms Metabolism and Immune Cell Infiltration in Actinic Keratosis

Topical Diclofenac Reprograms Metabolism and Immune Cell Infiltration in Actinic Keratosis

Background: Melanoma and squamous cell carcinoma of the skin are characterized by an altered glucose metabolism, but little is known about metabolic changes in precancerous skin lesions such as actinic keratosis (AK). Here, we studied the central carbon metabolism and immune cell infiltrate of actin...

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Bibliographic Details
Main Authors: Katrin Singer, Katja Dettmer, Petra Unger, Gabriele Schönhammer, Kathrin Renner, Katrin Peter, Peter J. Siska, Mark Berneburg, Wolfgang Herr, Peter J. Oefner, Sigrid Karrer, Marina Kreutz, Elisabeth Datz
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Oncology
Subjects:
actinic keratosis
diclofenac
CD8
CD1a
metabolism
lactate
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00605/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.00605/full

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