Tellurium Compounds Prevent and Reverse Type-1 Diabetes in NOD Mice by Modulating α4β7 Integrin Activity, IL-1β, and T Regulatory Cells

Tellurium Compounds Prevent and Reverse Type-1 Diabetes in NOD Mice by Modulating α4β7 Integrin Activity, IL-1β, and T Regulatory Cells

The study shows that treatment of NOD mice with either of two tellurium-based small molecules, AS101 [ammonium trichloro(dioxoethylene-o,o')tellurate] or SAS [octa-O-bis-(R,R)-tartarate ditellurane] could preserve β cells function and mass. These beneficial effects were reflected in decreased i...

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Bibliographic Details
Main Authors: Tom Eitan Yossipof, Ziva Roy Bazak, Dvora Kenigsbuch-Sredni, Rachel R. Caspi, Yona Kalechman, Benjamin Sredni
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
diabetes
tellurium
integrin
inflammation
IL-1β
Tregs
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00979/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00979/full

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