Analysis of Drug-Induced Gastrointestinal Obstruction and Perforation Using the Japanese Adverse Drug Event Report Database

Analysis of Drug-Induced Gastrointestinal Obstruction and Perforation Using the Japanese Adverse Drug Event Report Database

Drug-induced gastrointestinal obstruction (DIGO) and gastrointestinal perforation (DIGP) may be the result of gastrointestinal hypomotility and severe constipation, which may lead to potentially fatal complications of bowel ischemia, sepsis and perforation. We evaluated the onset profile of DIGs (DI...

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Bibliographic Details
Main Authors: Riko Satake, Kiyoka Matsumoto, Mizuki Tanaka, Ririka Mukai, Kazuyo Shimada, Yu Yoshida, Misaki Inoue, Shiori Hasegawa, Kazuhiro Iguchi, Hiroaki Ikesue, Shinya Shimizu, Shohei Nishida, Akio Suzuki, Tohru Hashida, Mitsuhiro Nakamura
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Pharmacology
Subjects:
The Japanese Adverse Drug Event Report
gastrointestinal obstruction
gastrointestinal perforation
ileus
pharmacovigilance
time-to-onset profile
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.692292/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.692292/full

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