Distinct Rab7-related Endosomal–Autophagic–Lysosomal Dysregulation Observed in Cortex and Hippocampus in APPswe/PSEN1dE9 Mouse Model of Alzheimer's Disease

Distinct Rab7-related Endosomal–Autophagic–Lysosomal Dysregulation Observed in Cortex and Hippocampus in APPswe/PSEN1dE9 Mouse Model of Alzheimer's Disease

Background: Amyloid-β deposition and accumulation of autophagic vacuoles are pathologic features of Alzheimer's disease (AD). Dysregulation of the endosomal–autophagic–lysosomal (EAL) pathway, which impairs amyloid precursor protein processing, is one of the earliest changes in AD. However, the...

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Bibliographic Details
Main Authors: Li Ba, Xiao-Hua Chen, Yan-Lin Chen, Qing Nie, Zhi-Jun Li, Feng-Fei Ding, Min Zhang
Format: Article
Language:English
Published: Wolters Kluwer 2017-01-01
Series:Chinese Medical Journal
Subjects:
Autophagy; Class III Phosphatidylinositol 3-Kinase Complex; Endocytosis; Neurodegeneration; Rab7
Online Access:http://www.cmj.org/article.asp?issn=0366-6999;year=2017;volume=130;issue=24;spage=2941;epage=2950;aulast=Ba

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http://www.cmj.org/article.asp?issn=0366-6999;year=2017;volume=130;issue=24;spage=2941;epage=2950;aulast=Ba

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